Document Detail

Epigenetic regulation of germ cell differentiation.
MedLine Citation:
PMID:  20951019     Owner:  NLM     Status:  MEDLINE    
Germ cells and somatic cells have the identical genome. However, unlike the mortal fate of somatic cells, germ cells have the unique ability to differentiate into gametes that retain totipotency and produce an entire organism upon fertilization. The processes by which germ cells differentiate into gametes, and those by which gametes become embryos, involve dramatic cellular differentiation accompanied by drastic changes in gene expression, which are tightly regulated by genetic circuitries as well as epigenetic mechanisms. Epigenetic regulation refers to heritable changes in gene expression that are not due to changes in primary DNA sequence. The past decade has witnessed an ever-increasing understanding of epigenetic regulation in many different cell types/tissues during embryonic development and adult homeostasis. In this review, we focus on recent discoveries of epigenetic regulation of germ cell differentiation in various metazoan model organisms, including worms, flies, and mammals.
Suk Ho Eun; Qiang Gan; Xin Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-13
Journal Detail:
Title:  Current opinion in cell biology     Volume:  22     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-03     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
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MeSH Terms
Cell Differentiation / physiology*
Embryonic Development / physiology
Epigenesis, Genetic*
Gene Expression Regulation, Developmental
Germ Cells / physiology*
Grant Support
R00 HD055052/HD/NICHD NIH HHS; R00 HD055052-05/HD/NICHD NIH HHS; R01 HD065816-02/HD/NICHD NIH HHS; R21 HD065089/HD/NICHD NIH HHS; R21 HD065089-02/HD/NICHD NIH HHS

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