| Epigenetic modifications may play a role in the developmental consequences of early life events. | |
| | |
MedLine Citation:
|
PMID: 21984032 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Many aspects of postnatal development are influenced by events before birth, including cognitive and language development. An adverse intrauterine environment, for example secondary to poor maternal nutritional status, multiple pregnancy, or late preterm birth, is associated with increased risks of delayed or impaired childhood development and altered physiology in adulthood that may predispose to increased risk of adult disease. Maternal periconceptional undernutrition and twin conception can both result in late preterm birth, but it is less clear whether cases of late preterm birth not following a recognized early pregnancy event may still have their origin in the periconceptional period. Thus, the very earliest periods of pregnancy, and perhaps even the pre-pregnancy period, may be an important period determining the developmental trajectory of the fetus, and thus both pregnancy and later health outcomes. Profound epigenetic modifications to the genome occur in the early embryo as a normal part of development. Recent evidence suggests that environmental signals acting during early development may also result in epigenetic changes which may play a role in mediating the association between early life exposures and later phenotype. |
| | |
Authors:
|
Frank H Bloomfield |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-8 |
Journal Detail:
|
Title: Journal of neurodevelopmental disorders Volume: - ISSN: 1866-1947 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101483832 Medline TA: J Neurodev Disord Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand, f.bloomfield@auckland.ac.nz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Superior mesenteric artery stent fracture leading to recurrent mesenteric ischemia.
Next Document: New Prodrugs of the Antiprotozoal Drug Pentamidine.