Document Detail

Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.
MedLine Citation:
PMID:  17544850     Owner:  NLM     Status:  MEDLINE    
Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight, leading to an increased risk of metabolic and cardiovascular illness in the offspring. We argue that these effects are, in part, mediated by direct and indirect effects on the hypothalamic-pituitary-adrenal (HPA) axis such that (i) the effect of maternal adversity on foetal growth is mediated by adrenal glucocorticoids and (ii) environmental adversity alters maternal physiology and behaviour, which then programs HPA activity in the offspring.
Michael J Meaney; Moshe Szyf; Jonathan R Seckl
Publication Detail:
Type:  Journal Article     Date:  2007-06-04
Journal Detail:
Title:  Trends in molecular medicine     Volume:  13     ISSN:  1471-4914     ISO Abbreviation:  Trends Mol Med     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-77     Citation Subset:  IM    
McGill Program for Study of Genes, Environment and Health, McGill University, Montreal, Canada.
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MeSH Terms
11-beta-Hydroxysteroid Dehydrogenase Type 2 / metabolism
Adrenal Glands / metabolism
Chromatin / metabolism
DNA Methylation
Disease / etiology
Epigenesis, Genetic / physiology*
Fetal Development*
Fetus / metabolism
Glucocorticoids / metabolism
Hypothalamo-Hypophyseal System / embryology*,  metabolism
Infant, Low Birth Weight
Infant, Newborn
Maternal-Fetal Exchange
Pituitary-Adrenal System / embryology*,  metabolism
Stress, Physiological / complications
Reg. No./Substance:
0/Chromatin; 0/Glucocorticoids; EC Dehydrogenase Type 2

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