Document Detail

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies.
MedLine Citation:
PMID:  19833297     Owner:  NLM     Status:  MEDLINE    
Epigenetic mechanisms such as DNA methylation and modifications to histone proteins regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms are involved in the development of many diseases, including cancer. The neurological disorder most intensely studied with regard to epigenetic changes is Rett syndrome; patients with Rett syndrome have neurodevelopmental defects associated with mutations in MeCP2, which encodes the methyl CpG binding protein 2, that binds to methylated DNA. Other mental retardation disorders are also linked to the disruption of genes involved in epigenetic mechanisms; such disorders include alpha thalassaemia/mental retardation X-linked syndrome, Rubinstein-Taybi syndrome, and Coffin-Lowry syndrome. Moreover, aberrant DNA methylation and histone modification profiles of discrete DNA sequences, and those at a genome-wide level, have just begun to be described for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and in other neurological disorders such as multiple sclerosis, epilepsy, and amyotrophic lateral sclerosis. In this Review, we describe epigenetic changes present in neurological diseases and discuss the therapeutic potential of epigenetic drugs, such as histone deacetylase inhibitors.
Rocio G Urdinguio; Jose V Sanchez-Mut; Manel Esteller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  8     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-11-16     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1056-72     Citation Subset:  IM    
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MeSH Terms
DNA / genetics*
DNA Methylation / drug effects
Genetics, Medical*
Histones / genetics,  metabolism
Nervous System Diseases / genetics*
Nervous System Neoplasms / genetics
Neurodegenerative Diseases / genetics
Reg. No./Substance:
0/Histones; 9007-49-2/DNA
Comment In:
Lancet Neurol. 2009 Nov;8(11):975-7   [PMID:  19833291 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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