Document Detail


Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment.
MedLine Citation:
PMID:  23332363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical neurologists and scientists who study multiple sclerosis face open questions regarding the integration of epidemiological data with genome-wide association studies and clinical management of patients. It is becoming evident that the interplay of environmental influences and individual genetic susceptibility modulates disease presentation and therapeutic responsiveness. The molecular mechanisms through which environmental signals are translated into changes in gene expression include DNA methylation, post-translational modification of nucleosomal histones, and non-coding RNAs. These mechanisms are regulated by families of specialised enzymes that are tissue selective and cell-type specific. A model of multiple sclerosis pathogenesis should integrate underlying risk related to genetic susceptibility with cell-type specific epigenetic changes occurring in the immune system and in the brain in response to ageing and environmental stimuli.
Authors:
Jimmy L Huynh; Patrizia Casaccia
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lancet neurology     Volume:  12     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-17     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  195-206     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Epigenesis, Genetic / physiology*
Gene Expression Regulation
Genome-Wide Association Study
Humans
Models, Molecular
Multiple Sclerosis / epidemiology,  genetics*,  pathology*,  therapy*
Grant Support
ID/Acronym/Agency:
1F31NS077504-01/NS/NINDS NIH HHS; 2R37NS042925-10/NS/NINDS NIH HHS; F31 NS077504/NS/NINDS NIH HHS; R01 NS052738/NS/NINDS NIH HHS; R01 NS069835/NS/NINDS NIH HHS; R01NS52738/NS/NINDS NIH HHS; R01NS69835/NS/NINDS NIH HHS; R37 NS042925/NS/NINDS NIH HHS
Comments/Corrections

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