Document Detail

Epigenetic mechanisms in memory and synaptic function.
MedLine Citation:
PMID:  22122279     Owner:  NLM     Status:  MEDLINE    
Although the term 'epigenetics' was coined nearly seventy years ago, its critical function in memory processing by the adult CNS has only recently been appreciated. The hypothesis that epigenetic mechanisms regulate memory and behavior was motivated by the need for stable molecular processes that evade turnover of the neuronal proteome. In this article, we discuss evidence that supports a role for neural epigenetic modifications in the formation, consolidation and storage of memory. In addition, we will review the evidence that epigenetic mechanisms regulate synaptic plasticity, a cellular correlate of memory. We will also examine how the concerted action of multiple epigenetic mechanisms with varying spatiotemporal profiles influence selective gene expression in response to behavioral experience. Finally, we will suggest key areas for future research that will help elucidate the complex, vital and still mysterious, role of epigenetic mechanisms in neural function and behavior.
Faraz A Sultan; Jeremy J Day
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Epigenomics     Volume:  3     ISSN:  1750-192X     ISO Abbreviation:  Epigenomics     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-04-16     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101519720     Medline TA:  Epigenomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-81     Citation Subset:  IM    
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MeSH Terms
Central Nervous System / physiology*
Chromatin / metabolism
CpG Islands / genetics
DNA Methylation / physiology*
Epigenesis, Genetic / physiology*
Gene Expression Regulation / physiology*
Histones / metabolism
Memory / physiology*
Models, Biological*
Neuronal Plasticity / physiology*
Neurons / physiology
Substance-Related Disorders / physiopathology
Synapses / physiology*
Grant Support
1F32DA029419/DA/NIDA NIH HHS; F32 DA029419/DA/NIDA NIH HHS; F32 DA029419-01A1/DA/NIDA NIH HHS
Reg. No./Substance:
0/Chromatin; 0/Histones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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