Document Detail

Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks?
MedLine Citation:
PMID:  23166395     Owner:  NLM     Status:  MEDLINE    
'Epigenetics' has been defined as the study of 'mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence'. Chromatin modifications are major carriers of epigenetic information that both reflect and affect the transcriptional states of underlying genes. Several histone modifications are key players that are responsible for classical epigenetic phenomena. However, the mechanisms by which cells pass their histone modifications to daughter cells through mitotic division remain to be unveiled. Here, we review recent progress in the field and conclude that epigenetic modifications are not precisely maintained at a near-mononucleosome level of precision. We also suggest that transcription repression may be maintained by a buffer system that can tolerate a certain degree of fluctuation in repressive histone modification levels. This buffer system protects the repressed genes from potential improper derepression triggered by chromatin modification-level fluctuation resulting from cellular events, such as the cell-cycle-dependent dilution of the chromatin modifications and local responses to environmental cues.
Chang Huang; Mo Xu; Bing Zhu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  368     ISSN:  1471-2970     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-04-25     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  20110332     Citation Subset:  IM    
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MeSH Terms
Chromatin Assembly and Disassembly
Epigenetic Repression*
Histones / genetics,  metabolism*
Inheritance Patterns*
Lysine / genetics,  metabolism*
Models, Genetic
Nucleosomes / genetics,  metabolism
S Phase
Saccharomyces cerevisiae / genetics,  metabolism
Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics,  metabolism
Transcription, Genetic*
Reg. No./Substance:
0/Histones; 0/Nucleosomes; 0/Silent Information Regulator Proteins, Saccharomyces cerevisiae; K3Z4F929H6/Lysine

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