| Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks? | |
| | |
MedLine Citation:
|
PMID: 23166395 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
'Epigenetics' has been defined as the study of 'mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence'. Chromatin modifications are major carriers of epigenetic information that both reflect and affect the transcriptional states of underlying genes. Several histone modifications are key players that are responsible for classical epigenetic phenomena. However, the mechanisms by which cells pass their histone modifications to daughter cells through mitotic division remain to be unveiled. Here, we review recent progress in the field and conclude that epigenetic modifications are not precisely maintained at a near-mononucleosome level of precision. We also suggest that transcription repression may be maintained by a buffer system that can tolerate a certain degree of fluctuation in repressive histone modification levels. This buffer system protects the repressed genes from potential improper derepression triggered by chromatin modification-level fluctuation resulting from cellular events, such as the cell-cycle-dependent dilution of the chromatin modifications and local responses to environmental cues. |
| | |
Authors:
|
Chang Huang; Mo Xu; Bing Zhu |
Related Documents
:
|
23614035 - Genome-wide analysis of the expansin gene superfamily reveals grapevine-specific struct... 23359205 - Gene copy-number polymorphism caused by retrotransposition in humans. 23386295 - Analysis of developmental control genes using virus-induced gene silencing. 11930015 - Gene expression analysis in schizophrenia: reproducible up-regulation of several member... 10353625 - Tetracycline-controlled expression but not toxicity of an attenuated diphtheria toxin m... 19017365 - Wt1 represses hox gene expression in the regulation of gynaecologic tumour histologic t... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 368 ISSN: 1471-2970 ISO Abbreviation: Philos. Trans. R. Soc. Lond., B, Biol. Sci. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2012-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503623 Medline TA: Philos Trans R Soc Lond B Biol Sci Country: England |
Other Details:
|
Languages: eng Pagination: 20110332 Citation Subset: IM |
Affiliation:
|
College of Biological Sciences, China Agricultural University, , Beijing 100094, Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers...
Next Document: Stem cell therapy: an exercise in patience and prudence.