Document Detail

Epigenetic inheritance of cell differentiation status.
MedLine Citation:
PMID:  18418041     Owner:  NLM     Status:  MEDLINE    
Epigenetic modifications influence gene expression pattern and provide a unique signature of a cell differentiation status. Without external stimuli or signalling events, this cell identity remains stable and unlikely to change over many cell divisions. The epigenetic signature of a particular cell fate therefore needs to be replicated faithfully in daughter cells; otherwise a cell lineage cannot be maintained. However, the mechanism of transmission of cellular memory from mother to daughter cells remains unclear. It has been suggested that the inheritance of an active or silent gene state involves different kinds of epigenetic mechanisms, e.g. DNA methylation, histone modifications, replacement of histone variants, Polycomb group (PcG) and Trithorax group (TrxG) proteins. Emerging evidence supports the role of histone variant H3.3 in maintaining an active gene status and in remodelling nucleosomal composition. Here we discuss some recent findings on the propagation of epigenetic memory and propose a model for the inheritance of an active gene state through the interaction of H3.3 with other epigenetic components.
Ray K Ng; John B Gurdon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-19
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  7     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-07-18     Revised Date:  2008-09-23    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1173-7     Citation Subset:  IM    
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom.
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MeSH Terms
Cell Differentiation / genetics*
Cell Lineage / genetics*
Chromatin Assembly and Disassembly / genetics
Epigenesis, Genetic / genetics*
Gene Expression Regulation / genetics
Histones / genetics*
Inheritance Patterns / genetics*
Models, Biological
Nucleosomes / genetics
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Histones; 0/Nucleosomes

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