| Epigenetic inheritance of cell differentiation status. | |
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MedLine Citation:
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PMID: 18418041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epigenetic modifications influence gene expression pattern and provide a unique signature of a cell differentiation status. Without external stimuli or signalling events, this cell identity remains stable and unlikely to change over many cell divisions. The epigenetic signature of a particular cell fate therefore needs to be replicated faithfully in daughter cells; otherwise a cell lineage cannot be maintained. However, the mechanism of transmission of cellular memory from mother to daughter cells remains unclear. It has been suggested that the inheritance of an active or silent gene state involves different kinds of epigenetic mechanisms, e.g. DNA methylation, histone modifications, replacement of histone variants, Polycomb group (PcG) and Trithorax group (TrxG) proteins. Emerging evidence supports the role of histone variant H3.3 in maintaining an active gene status and in remodelling nucleosomal composition. Here we discuss some recent findings on the propagation of epigenetic memory and propose a model for the inheritance of an active gene state through the interaction of H3.3 with other epigenetic components. |
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Authors:
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Ray K Ng; John B Gurdon |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-02-19 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-07-18 Revised Date: 2008-09-23 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1173-7 Citation Subset: IM |
Affiliation:
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Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / genetics* Cell Lineage / genetics* Chromatin Assembly and Disassembly / genetics Epigenesis, Genetic / genetics* Gene Expression Regulation / genetics Histones / genetics* Humans Inheritance Patterns / genetics* Models, Biological Nucleosomes / genetics |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Histones; 0/Nucleosomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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