Document Detail


Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity.
MedLine Citation:
PMID:  18172431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disturbances of volume-regulating mechanisms have already been implicated in the pathophysiology of eating disorders like anorexia or bulimia nervosa with the peptide hormones vasopressin and atrial natriuretic peptide (ANP) being of special interest. Aim of the present study was to investigate, whether the expression of the corresponding genes was altered and if so, if these changes could be explained by epigenetic mechanisms such as DNA methylation. We analyzed blood samples of 46 women suffering from anorexia (n=22) or bulimia nervosa (n=24) as well as of 30 healthy controls. Peripheral mRNA expression and DNA methylation of the vasopressin and the ANP precursor genes were assessed using real-time PCR. We found significantly lower levels of ANP mRNA in patients with eating disorders. This downregulation was accompanied by a hypermethylation of the ANP gene promoter in the bulimic subgroup. We did not find differences regarding expression or methylation of the vasopressin gene. ANP mRNA expression was inversely associated with impaired impulse regulation. We conclude that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders.
Authors:
Helge Frieling; Stefan Bleich; Jeannette Otten; Konstanze D Römer; Johannes Kornhuber; Martina de Zwaan; Georg E Jacoby; Julia Wilhelm; Thomas Hillemacher
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-02
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  33     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-12     Completed Date:  2009-04-22     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2605-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. helge.frieling@uk-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Atrial Natriuretic Factor / antagonists & inhibitors*,  genetics,  metabolism*
DNA Methylation / genetics
Down-Regulation / genetics*
Eating Disorders / genetics*,  metabolism
Epigenesis, Genetic / genetics*
Female
Gene Expression Regulation / genetics
Humans
Impulsive Behavior / genetics*,  metabolism
Middle Aged
Promoter Regions, Genetic
RNA, Messenger / antagonists & inhibitors,  biosynthesis*
Vasopressins / biosynthesis*,  genetics
Chemical
Reg. No./Substance:
0/RNA, Messenger; 11000-17-2/Vasopressins; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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