| Epigenetic control in immune function. | |
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MedLine Citation:
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PMID: 21627041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This chapter describes recent advances in our understanding how epigenetic events control immune functions with emphasis on transcriptional regulation of major histocompatibility complex ClassI (MIC-I) and Class II (MHC-II) genes. MHC-I and MHC-II molecules play an essential role in the adaptive immune response by virtue of their ability to present peptides, respectively to CD8+ and CD4+ T cells. Central to the onset of an adequate immune response to pathogens is the presentation of pathogen-derived peptides in the context of MHC-II molecules by antigen presenting cells (APCs) to CD4+ T cells of the immune system. In particular dendritic cells are highly specialized APCs that are capable to activate naïve T cells. Given their central role in adaptive immunity, MHC-I and MHC-II genes are regulated in a tight fashion at the transcriptional level to meet with local requirements of an effective antigen-specific immune response. In these regulatory processes the MHC2TA encoded Class II transactivator (CIITA) plays a crucial role. CIITA is essential for transcriptional activation of all MHC-I genes, whereas it plays an ancillary function in the transcriptional control of MHC-I genes. The focus of this chapter therefore will be on the transcription factors that interact with conserved cis-acting promoter elements and epigenetic mechanisms that modulate cell type-specific regulation of MHC-I, MHC-I, and MHC2TA genes. Furthermore, we will also briefly discuss how genetic and epigenetic mechanisms contribute to T helper cell differentiation. |
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Authors:
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Peter J van den Elsen; Marja C J A van Eggermond; Rutger J Wierda |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 711 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-01 Completed Date: 2011-06-09 Revised Date: 2011-06-21 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 36-49 Citation Subset: IM |
Affiliation:
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Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands. pjvdelsen@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation Cell Differentiation Epigenesis, Genetic* Gene Expression Regulation Humans Immunity* Major Histocompatibility Complex Nuclear Proteins / genetics, physiology* T-Lymphocytes, Helper-Inducer / cytology Trans-Activators / genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/MHC class II transactivator protein; 0/Nuclear Proteins; 0/Trans-Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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