| Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. | |
| | |
MedLine Citation:
|
PMID: 18178212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Lower activity of 11 beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) classically induces hypertension by leading to an altered tetrahydrocortisol- versus tetrahydrocortisone-metabolites (THFs/THE) shuttle. Recent cell culture and animal studies suggest a role for promoter methylation, a major epigenetic feature of DNA, in regulation of HSD11B2 expression. Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension. OBJECTIVE: To explore the possible relevance of HSD11B2 promoter methylation, by examining human peripheral blood mononuclear cell (PBMC) DNA and urinary THFs/THE ratio as a biochemical indicator of 11beta-HSD2 activity, in blood pressure control. METHODS: Twenty-five essential hypertensives and 32 subjects on prednisone therapy were analyzed, the latter to investigate 11beta-HSD2 function in the development of hypertension. RESULTS: Elevated HSD11B2 promoter methylation was associated with hypertension developing in glucocorticoid-treated patients in parallel with a higher urinary THFs/THE ratio. Essential hypertensives with elevated urinary THFs/THE ratio also showed higher HSD11B2 promoter methylation. CONCLUSIONS: These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension. |
| | |
Authors:
|
Simonetta Friso; Francesca Pizzolo; Sang-Woon Choi; Patrizia Guarini; Annalisa Castagna; Viviana Ravagnani; Antonio Carletto; Patrizia Pattini; Roberto Corrocher; Oliviero Olivieri |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-07 |
Journal Detail:
|
Title: Atherosclerosis Volume: 199 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-07-28 Completed Date: 2008-11-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 323-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy. simonetta.friso@univr.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
11-beta-Hydroxysteroid Dehydrogenase Type 2
/
genetics* Aged DNA / metabolism DNA Methylation Epigenesis, Genetic* Female Glucocorticoids / metabolism Humans Hypertension / genetics* Leukocytes, Mononuclear / cytology, metabolism Male Middle Aged Prednisone / therapeutic use Promoter Regions, Genetic* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 53-03-2/Prednisone; 9007-49-2/DNA; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasi...
Next Document: Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardio...