Document Detail

Epigenetic concerns in assisted reproduction: update and critical review of the current literature.
MedLine Citation:
PMID:  23714435     Owner:  NLM     Status:  In-Data-Review    
More than 4 million children have been born through the use of human in vitro fertilization (IVF), a technology that emerged only 35 years ago and is still dynamically evolving. Despite its very good initial safety profile, reports of increased prevalence of human perinatal problems and evidence obtained from animal experiments raise concerns that the occurrence of epigenetic anomalies might be increased as a result of infertility etiologies, ovarian stimulation, and extracorporeal handling and culture of gametes and embryos. This issue's Views and Reviews section aims to describe the basic mechanisms of epigenetics and to summarize the current knowledge obtained from animal experiments and human IVF practice, to shed light on the possible association between epigenetic disturbances and assisted reproduction technologies.
Yoel Shufaro; Neri Laufer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  99     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-05-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
IVF Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel. Electronic address:
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