Document Detail


Epigenetic choreographers of neurogenesis in the adult mammalian brain.
MedLine Citation:
PMID:  20975758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can lead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.
Authors:
Dengke K Ma; Maria Carolina Marchetto; Junjie U Guo; Guo-li Ming; Fred H Gage; Hongjun Song
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature neuroscience     Volume:  13     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-11-12     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1338-44     Citation Subset:  IM    
Affiliation:
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain* / cytology,  embryology,  growth & development
Brain Neoplasms / genetics,  physiopathology
Cell Differentiation
DNA Methylation
Epigenesis, Genetic*
Humans
Mental Disorders / genetics,  pathology,  physiopathology
Models, Biological
Neurogenesis / physiology*
Neurons / physiology*
Stem Cells / physiology
Grant Support
ID/Acronym/Agency:
AG024984/AG/NIA NIH HHS; HD069184/HD/NICHD NIH HHS; MH087874/MH/NIMH NIH HHS; MH088485/MH/NIMH NIH HHS; MH090258/MH/NIMH NIH HHS; NS047344/NS/NINDS NIH HHS; NS048271/NS/NINDS NIH HHS; R01 MH088485-02/MH/NIMH NIH HHS; R01 MH090258-01/MH/NIMH NIH HHS
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