| Epigenetic causes of apoptosis resistance in cutaneous T-cell lymphomas. | |
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MedLine Citation:
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PMID: 20231830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In cutaneous T-cell lymphomas (CTCLs) defects in Fas-mediated apoptosis have been suggested to be involved in disease pathogenesis. Decreased or absent Fas expression has been reported in a significant proportion of CTCL patients, but the molecular mechanisms of such impaired Fas expression have hardly been investigated to date. In this issue, Jones et al. show that defective Fas expression is attributable to positional methylation of the Fas gene. |
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Authors:
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Emmanuel Contassot; Lars E French |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 130 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-16 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 922-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University Hospital, Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95
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genetics Apoptosis / physiology* DNA Methylation / physiology Epigenesis, Genetic / physiology* Humans Lymphoma, T-Cell / genetics, pathology, physiopathology* Skin Neoplasms / genetics, pathology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/FAS protein, human |
| Comments/Corrections | |
Comment On:
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J Invest Dermatol. 2010 Apr;130(4):1116-25
[PMID:
19759548
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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