Document Detail

Epigenetic causes of apoptosis resistance in cutaneous T-cell lymphomas.
MedLine Citation:
PMID:  20231830     Owner:  NLM     Status:  MEDLINE    
In cutaneous T-cell lymphomas (CTCLs) defects in Fas-mediated apoptosis have been suggested to be involved in disease pathogenesis. Decreased or absent Fas expression has been reported in a significant proportion of CTCL patients, but the molecular mechanisms of such impaired Fas expression have hardly been investigated to date. In this issue, Jones et al. show that defective Fas expression is attributable to positional methylation of the Fas gene.
Emmanuel Contassot; Lars E French
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  130     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-16     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  922-4     Citation Subset:  IM    
Department of Dermatology, University Hospital, Zurich, Switzerland.
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MeSH Terms
Antigens, CD95 / genetics
Apoptosis / physiology*
DNA Methylation / physiology
Epigenesis, Genetic / physiology*
Lymphoma, T-Cell / genetics,  pathology,  physiopathology*
Skin Neoplasms / genetics,  pathology,  physiopathology*
Reg. No./Substance:
0/Antigens, CD95; 0/FAS protein, human
Comment On:
J Invest Dermatol. 2010 Apr;130(4):1116-25   [PMID:  19759548 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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