Document Detail

Epigenetic-based therapies in cancer: progress to date.
MedLine Citation:
PMID:  22141383     Owner:  NLM     Status:  In-Data-Review    
Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic changes are DNA methylation and histone modification. These modifications are catalysed by DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), resulting in chromatin structure changes and gene inactivation. Interestingly, inhibition of these enzymes is known to induce differentiation or apoptosis of cancer cells. Therefore, DNMTs and HDACs have become attractive therapeutic targets. In recent years, many different DNMT and HDAC inhibitors have been developed, and multiple molecular mechanisms through which these agents exert anti-cancer effects have been identified. While a large number of clinical trials are ongoing, hypomethylating agents and HDAC inhibitors seem to be promising for treating several types of cancer. Moreover, developing effective strategies of combining epigenetic therapy with conventional chemotherapy will be one of the major challenges in the future. We briefly review current advances in epigenetic therapies with a focus on recently reported clinical trials.
Sang-Hyun Song; Sae-Won Han; Yung-Jue Bang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs     Volume:  71     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  2391-403     Citation Subset:  IM    
Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
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