Document Detail

Epigenetic aspects of X-chromosome dosage compensation.
MedLine Citation:
PMID:  11498577     Owner:  NLM     Status:  MEDLINE    
The X chromosomes of mammals and fruit flies exhibit unusual properties that have evolved to deal with the different dosages of X-linked genes in males (XY) and females (XX). The X chromosome dosage-compensation mechanisms discovered in these species are evolutionarily unrelated, but exhibit surprising parallels in their regulatory strategies. These features include the importance of noncoding RNAs, and epigenetic spreading of chromatin-modifying activities. Sex chromosomes have posed a fascinating puzzle for biologists. The dissimilar organization, gene content, and regulation of the X and Y chromosomes are thought to reflect selective forces acting on original pairs of identical chromosomes (1-3). The result in many organisms is a male-specific Y chromosome that has lost most of its original genetic content, and a difference in dosage of the X chromosome in males (XY) and females (XX).
Y Park; M I Kuroda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  293     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-10     Completed Date:  2001-09-06     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-5     Citation Subset:  IM    
Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
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MeSH Terms
Chromatin / metabolism
Dosage Compensation, Genetic*
Drosophila / genetics
Evolution, Molecular
Genomic Imprinting
Histones / metabolism
Mammals / genetics
RNA, Untranslated / genetics,  metabolism
RNA-Binding Proteins / metabolism
Transcription Factors / genetics,  metabolism
Transcription, Genetic
X Chromosome / genetics*
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/RNA, Untranslated; 0/RNA-Binding Proteins; 0/Transcription Factors; 0/X (inactive)-specific transcript (XIST)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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