Document Detail

Epigenetic alterations in hematopoietic malignancies.
MedLine Citation:
PMID:  23015417     Owner:  NLM     Status:  Publisher    
Gene discovery efforts in patients with hematopoietic malignancies have brought to the forefront a series of mutations in genes thought to be involved in the epigenetic regulation of gene transcription. These mutations occur in genes known, or suspected, to play a role in modifying cytosine nucleotides on DNA and/or altering the state of histone modifications. Genes such as ASXL1, DNMT3A, EZH2, IDH1/2, MLL1, and TET2 all have been shown to be mutated and/or translocated in patients with myeloid malignancies. Intriguingly, many of the alterations affecting DNA cytosine modifications in myeloid malignancies (mutations in DNMT3A, IDH1/2, and TET2) have also been found in patients with T-cell lymphomas, and EZH2 mutations appear to be critical in T-cell acute lymphoblastic leukemia development as well. In addition, the discovery of frequent mutations in CREBBP, EP300, EZH2, and MLL2 in B-cell lymphomas suggests that epigenetic alterations play a critical role in lymphomagenesis. The purpose of this review is to present functional evidence of how alterations in these epigenetic modifiers promote hematopoietic transformation. The conclusions drawn from these data are valuable in understanding biological mechanisms and potential therapeutic targets.
Young Rock Chung; Emma Schatoff; Omar Abdel-Wahab
Related Documents :
19691827 - Prb2/p130 protein expression and rbl2 mutation analysis in burkitt lymphoma from uganda.
11418487 - Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather t...
7845677 - Mutational hot spots within the carboxy terminal region of the lmp1 oncogene of epstein...
10343157 - Immunoglobulin allotypes among the bicolanos of sorsogon province, luzon, philippines: ...
20678067 - Hypothermia and alzheimer's disease neuropathogenic pathways.
20121287 - Variant vkorc1 and cyp2c9 alleles in patients with diffuse alveolar hemorrhage caused b...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  International journal of hematology     Volume:  -     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of season, browse species and polyethylene glycol addition on gas production kinetics of for...
Next Document:  Crystal Growth, Structure, and Magnetic Properties of a Two-dimensional Triangular Lattice Magnet, C...