Document Detail


Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future.
MedLine Citation:
PMID:  23211398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased understanding about the functional complexity of the genome has led to growing recognition about the role of epigenetic variation in the etiology of schizophrenia. Epigenetic processes act to dynamically control gene expression independently of DNA sequence variation and are known to regulate key neurobiological and cognitive processes in the brain. To date, our knowledge about the role of epigenetic processes in schizophrenia is limited and based on analyses of small numbers of samples obtained from a range of different cell and tissue types. Moving forward, it will be important to establish cause and effect in epigenetic studies of schizophrenia and broaden our horizons beyond DNA methylation. Rather than investigating genetic and epigenetic factors independently, an integrative etiological research paradigm based on the combination of genomic, transcriptomic, and epigenomic analyses is required.
Authors:
Emma Dempster; Joana Viana; Ruth Pidsley; Jonathan Mill
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-12-04
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  39     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-21     Completed Date:  2013-06-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA Methylation / genetics
Epigenesis, Genetic / genetics*
Epigenomics / methods*,  trends*
Forecasting
Humans
Schizophrenia / etiology*,  genetics
Comments/Corrections

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