Document Detail

Epigallocatechin gallate. The major causative agent of green tea-induced asthma.
MedLine Citation:
PMID:  7988204     Owner:  NLM     Status:  MEDLINE    
We describe three patients who worked in green tea factories and developed asthmatic and nasal symptoms after exposure to green tea dust. To clarify what component(s) of green tea leaves might be responsible for causing asthma, we prepared catechins, the major components of green tea leaves. Epigallocatechin gallate (EGCg; MW: 458 daltons), a major catechin, was purified by high-performance liquid chromatography. Subjects included three patients with green tea-induced asthma, five asthmatics with no previous exposure to tea dust, and five healthy controls. It was found that all three patients exhibited an immediate skin and bronchial response to EGCg. Prausnitz-Küstner test with EGCg was also positive. However, none of the asthmatic and healthy controls showed a positive reaction. These results indicate that EGCg is a causative agent of green tea-induced asthma and suggest that an IgE-mediated response is, at least in part, responsible for causing this type of occupational asthma.
T Shirai; A Sato; Y Hara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  106     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-10     Completed Date:  1995-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1801-5     Citation Subset:  AIM; IM    
Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Asthma / chemically induced*,  diagnosis
Bronchial Provocation Tests
Catechin / adverse effects,  analogs & derivatives*
Dust / adverse effects*
Intradermal Tests
Middle Aged
Occupational Diseases / chemically induced*
Skin Tests
Tea / adverse effects*
Reg. No./Substance:
0/Dust; 0/Tea; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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