| Epigallocatechin-3-gallate increases maximal oxygen uptake in adult humans. | |
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MedLine Citation:
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PMID: 19952844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We have investigated the hypothesis that short-term consumption of EGCG delays the onset of the ventilatory threshold (VT) and increases maximal oxygen uptake (VO2max). METHODS: In this randomized, repeated-measures, double-blind study, 19 healthy adults (11 males and 8 females, age = 26 ± 2 yr (mean ± SE)) received seven placebo or seven EGCG (135-mg) pills. Forty-eight hours before data collection, participants began consuming three pills per day; the last pill was taken 2 h before exercise testing. VT and VO2max were determined from breath-by-breath indirect calorimetry data collected during continuous incremental stationary cycle ergometer exercise (20-35 W·min(-1)), from rest until volitional fatigue. Each condition/exercise test was separated by a minimum of 14 d. RESULTS: Compared with placebo, short-term EGCG consumption increased VO2max (3.123 ± 0.187 vs 3.259 ± 0.196 L·min(-1), P = 0.04). Maximal work rate (301 ± 15 vs 301 ± 16 W, P = 0.98), maximal RER (1.21 ± 0.01 vs 1.22 ± 0.02, P = 0.27), and maximal HR were unaffected (180 ± 3 vs 180 ± 3 beats·min(-1), P = 0.87). In a subset of subjects (n = 11), maximal cardiac output (determined via open-circuit acetylene breathing) was also unaffected by EGCG (29.6 ± 2.2 vs 30.2 ± 1.4 L·min(-1), P = 0.70). Contrary to our hypothesis, EGCG decreased VO2 at VT (1.57 ± 0.11 vs 1.48 ± 0.10 L·min(-1)), but this change was not significant (P = 0.06). CONCLUSIONS: Short-term consumption of EGCG increased VO2max without affecting maximal cardiac output, suggesting that EGCG may increase arterial-venous oxygen difference. |
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Authors:
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Jennifer C Richards; Mark C Lonac; Tyler K Johnson; Melani M Schweder; Christopher Bell |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 42 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2011-04-07 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 739-44 Citation Subset: IM; S |
Affiliation:
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Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523-1582, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / pharmacology* Catechin / analogs & derivatives*, pharmacology Double-Blind Method Female Humans Male Maximal Voluntary Ventilation / drug effects Oxygen Consumption / drug effects* Physical Endurance / drug effects, physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AG022053/AG/NIA NIH HHS; K01 AG022053-06/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate |
| Comments/Corrections | |
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