| (-)-Epigallocatechin 3-gallate (EGCG) at the ocular surface inhibits corneal neovascularization. | |
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MedLine Citation:
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PMID: 20971568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Corneal neovascularization is often accompanied by inflammatory response and loss of their immune privilege which leads to significant visual impairment and worsens the prognosis of a subsequent penetrating keratoplasty. Several types of treatment are currently used. However, there are some associated limitations and complications. The consumption of (-)-epigallocatechin 3-gallate (EGCG) has been studied extensively as a potential treatment for a variety of carcinogenic and degenerative diseases due to its ability to suppress a variety of inflammatory and angiogenic factors such as NF-κB, IL-1β, COX2, VEGF, and matrix metalloproteinases. These factors are involved in the development of corneal neovascularization. The safety of long-term EGCG administration as well as the drug's high solubility in water urge further investigation of the therapeutic potential of this drug. Therefore, we propose that the administration of EGCG to the ocular surface represents a new chemopreventive alternative to suppress the corneal neovascularization induced by inflammation. |
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Authors:
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V Sánchez-Huerta; L Gutiérrez-Sánchez; J Flores-Estrada |
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Publication Detail:
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Type: Journal Article Date: 2010-10-23 |
Journal Detail:
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Title: Medical hypotheses Volume: 76 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 311-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Asociación Para Evitar la Ceguera en México, Vicente García Torres No. 46, Col. San Lucas Coyoacán, CP 04030, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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