Document Detail

Epidural volume extension in combined spinal epidural anaesthesia for elective caesarean section: a randomised controlled trial.
MedLine Citation:
PMID:  21418045     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of epidural volume extension on spinal blockade in pregnant women undergoing elective caesarean section with a combined spinal-epidural technique. We randomly allocated 90 healthy subjects to three groups to receive spinal hyperbaric bupivacaine 7.5 mg (group B7.5), spinal hyperbaric bupivacaine 7.5 mg immediately followed by epidural volume extension with saline 5 ml (group B7.5-EVE) or spinal hyperbaric bupivacaine 10 mg without epidural volume extension (group B10). We evaluated the height of the block every 5 min for 15 min following the spinal injection. The overall sensory block level increased with time (p < 0.001), regardless of the group studied, and there were significantly fewer failures of block in the group B10 compared with both B7.5 and B7.5-EVE groups (p = 0.001). In conclusion, we could not demonstrate a benefit in using epidural volume extension with 5 ml saline as part of a combined spinal epidural technique in term parturients undergoing elective caesarean section.
C Loubert; P J O'Brien; R Fernando; N Walton; S Philip; T Addei; M O Columb; S Hallworth
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-03-18
Journal Detail:
Title:  Anaesthesia     Volume:  66     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-06-06     Revised Date:  2012-09-06    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  AIM; IM    
Copyright Information:
© 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.
University College London Hospitals NHS Foundation Trust, London, UK.
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MeSH Terms
Anesthesia, Epidural / adverse effects,  methods*
Anesthesia, Obstetrical / adverse effects,  methods*
Anesthesia, Spinal / adverse effects,  methods*
Anesthetics, Local / administration & dosage,  adverse effects
Apgar Score
Bupivacaine / administration & dosage,  adverse effects
Cesarean Section*
Dose-Response Relationship, Drug
Double-Blind Method
Movement / drug effects
Prospective Studies
Sensation / drug effects
Sodium Chloride / administration & dosage
Grant Support
//Department of Health
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine; 7647-14-5/Sodium Chloride
Comment In:
Anaesthesia. 2012 Aug;67(8):927-8; author reply 928-9   [PMID:  22775383 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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