Document Detail

Epidural spinal electrical stimulation for severe angina: a study of its effects on symptoms, exercise tolerance and degree of ischaemia.
MedLine Citation:
PMID:  1618204     Owner:  NLM     Status:  MEDLINE    
The effectiveness of epidural spinal electrical stimulation has been studied in 14 patients with severe intractable angina unresponsive to standard therapies including bypass grafting. After implantation of the neurostimulator units the patients were assessed by a symptom questionnaire, treadmill exercise testing and right atrial pacing. There was a significant improvement of symptoms and GTN consumption fell markedly. With the neurostimulator on, exercise duration increased from a mean (CI) of 414 (153) to 478 (149) s, and total ST segment depression was less both at maximum exercise (7.1 (4.5) vs 5.6 (4.2) mm) and at 90% of the maximum control heart rate (3.5 (3.7) vs 2.6 (4.3) mm), with similar rate-pressure product at maximum exercise. With right atrial pacing the maximum heart rate reached before onset of angina was increased (143 (14) to 150 (7) b.min-1) and total ST segment depression was less at all heart rates. Benefit has persisted in some patients for over 2 years without any apparent adverse sequelae. Epidural spinal electrical stimulation is, therefore, an alternative therapy for some patients with intractable angina which has not responded to standard therapies.
J E Sanderson; P Brooksby; D Waterhouse; R B Palmer; K Neubauer
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  628-33     Citation Subset:  IM    
Department of Cardiology, Taunton and Somerset Hospital, U.K.
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MeSH Terms
Angina Pectoris / etiology,  physiopathology,  rehabilitation,  therapy*
Blood Pressure / physiology
Coronary Disease / complications*,  physiopathology
Electrodes, Implanted
Epidural Space
Exercise Test
Ganglia, Spinal*
Heart Rate / physiology
Middle Aged
Severity of Illness Index
Transcutaneous Electric Nerve Stimulation / instrumentation,  methods*
Work Capacity Evaluation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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