Document Detail

Epidural fentanyl and caesarean section: when should fentanyl be given?
MedLine Citation:
PMID:  1563055     Owner:  NLM     Status:  MEDLINE    
Epidural fentanyl is often added to epidural local anaesthetic agents to improve the quality of anaesthesia obtained during Caesarean section. Fentanyl may be given either before or after delivery of the infant. When given before delivery, fentanyl has not been reported to cause neonatal depression, although this remains a concern. A prospective, randomized, double-blind study was undertaken to determine if fentanyl was more effective if given before or after delivery of the baby in 64 women undergoing Caesarean section under lidocaine epidural anaesthesia. Maternal outcome was determined by time to achieve T4 neural blockade, the dose of lidocaine necessary to achieve this block and intraoperative scores for pain, nausea, vomiting, shivering, and sedation. Neonates were assessed by umbilical arterial blood pH and Apgar scores. No differences were detected in either group with respect to maternal or neonatal outcome. We recommend using only epidural local anaesthetic agents before delivery, and giving epidural fentanyl following delivery of the infant.
T W Breen; J A Janzen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  39     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Department of Anaesthesia, Foothills Hospital, University of Calgary, Alberta.
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MeSH Terms
Anesthesia, Epidural*
Anesthesia, Obstetrical*
Apgar Score
Cesarean Section*
Double-Blind Method
Fentanyl / administration & dosage*,  blood
Fetal Blood / chemistry,  physiology
Hydrogen-Ion Concentration
Intraoperative Complications / prevention & control
Lidocaine / administration & dosage
Pain / prevention & control
Pregnancy Outcome
Prospective Studies
Treatment Outcome
Reg. No./Substance:
137-58-6/Lidocaine; 437-38-7/Fentanyl
Comment In:
Can J Anaesth. 1993 Aug;40(8):796   [PMID:  8403164 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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