| Epidural anesthesia may attenuate lipid peroxidation during aorto-femoral surgery. | |
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MedLine Citation:
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PMID: 15128632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the effect of epidural anesthesia (EP) on oxygenation of the chronically ischemic limb in patients undergoing aorto-femoral bypass grafting and to assess whether it produces an alteration of lipid peroxidation and antioxidant status following revascularization. METHODS: In this prospective, randomized, single-blinded study 40 ASA II or III patients undergoing elective aorto-femoral bypass grafting were allocated to receive general anesthesia (group GA, n = 20), or epidural + GA (group EP, n = 20) during surgery. Femoral venous blood-gas status, activities of the protecting antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-px), glutathione reductase (GSH-rd), glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) as a marker of lipid peroxidation were determined in blood samples taken from the femoral vein at different intervals before and after revascularization. RESULTS: Before the induction of anesthesia in group EP, femoral venous PO(2) [mean (standard deviation), 95% confidence interval] increased after achieving an adequate level of blockade by EP extending to the dermatomal level of T6-8 [29.32 (4.6), 26.34-32.30 to 36.29 (4.6), 33.37-39.22 mmHg, P < 0.05]. Femoral venous PO(2) was similar in both groups thereafter. In the GA group a significant increase in erythrocyte TBARS was observed immediately after restoration of blood flow when compared with baseline values [221.32 (102), 148.35-294-29 to 337.26 (123) 248.99-425.53 nmol*g(-1) hemoglobin, P < 0.01] but not at any other moment. In the EP group TBARS did not increase throughout the study. Within group comparisons revealed no significant differences in GSH, GSH-px, GSH-rd and SOD. CONCLUSION: In patients with atherosclerotic aorto-iliac occlusive disease EP may possibly attenuate lipid peroxidation following revascularization but has no effect on antioxidant enzyme activities. |
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Authors:
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Lale Yüceyar; Hülya Erolçay; Dildar Konukoglu; A Kürsat Bozkurt; Bora Aykaç |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 51 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-06 Completed Date: 2004-09-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: Canada |
Other Details:
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Languages: eng Pagination: 465-71 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. Lyuceyar@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthesia, Epidural* Anesthesia, General Antioxidants / metabolism Arterial Occlusive Diseases / surgery* Arteriosclerosis / surgery* Blood Gas Analysis Erythrocytes / enzymology, metabolism Female Femoral Vein / surgery* Glutathione Peroxidase / blood Glutathione Reductase / blood Hemodynamics / physiology Humans Lipid Peroxidation / physiology* Male Middle Aged Myocardial Reperfusion Myocardial Revascularization* Superoxide Dismutase / blood Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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