| Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis. | |
| | |
MedLine Citation:
|
PMID: 16521220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To investigate the effect of epidural anaesthesia (EA) on pancreatic microcirculation during acute pancreatitis (AP). METHODS: AP was induced by injection of sodium taurocholate into the pancreatic duct of Sprague-Dawley rats. To realize EA, a catheter was introduced into the epidural space between T7 and T9 and bupivacaine was injected. Microcirculatory flow was measured by laser Doppler flowmetry. Arterial blood gas analyses were performed. At the end of the experiment (<or=5 h), pancreas was removed for histology. The animals were divided into three groups: Group 1 (n=9), AP without EA; Group 2 (n=4), EA without AP; and Group 3 (n=6), AP treated by EA. RESULTS: In Group 1, pancreatic microcirculatory flow prior to AP was 141+/- 39 perfusion units (PU). After AP, microcirculatory flow obviously decreased to 9+/- 6 PU (P<0.05). Metabolic acidosis developed with base excess (BE) of -14+/-3 mmol/L. Histology revealed extensive edema and tissue necrosis. In Group 2, EA did not significantly modify microcirculatory flow. BE remained unchanged and histological analysis showed normal pancreatic tissue. In Group 3, AP initially caused a significant decrease in microcirculatory flow from 155+/-25 to 11+/-7 PU (P<0.05). After initiation of EA, microcirculatory flow obviously increased again to 81+/-31 PU (P<0.05). BE was -6+/-4 mmol/L, which was significantly different compared to Group 1 (P<0.05). Furthermore, histology revealed less extensive edema and necrosis in pancreatic tissue in Group 3 than that in Group 1. CONCLUSION: AP caused dramatic microcirculatory changes within the pancreas, with development of metabolic acidosis and tissue necrosis. EA allowed partial restoration of microcirculatory flow and prevented development of tissue necrosis and systemic complications. Therefore, EA should be considered as therapeutic option to prevent evolution from edematous to necrotic AP. |
| | |
Authors:
|
Alp Demirag; Catherine M Pastor; Philippe Morel; Copin Jean-Christophe; Andreas W Sielenkämper; Nilgun Güvener; Gang Mai; Thierry Berney; Jean-Louis Frossard; Leo H Bühler |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 12 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-03-07 Completed Date: 2006-05-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 915-20 Citation Subset: IM |
Affiliation:
|
Surgical Research Unit, Department of Surgery, University Hospital Geneva, 24, Rue Micheli-du-Crest, 1211, Geneva 14, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Anesthesia, Epidural* / methods Animals Disease Models, Animal Hindlimb Isoflurane Male Microcirculation / drug effects* Motor Activity Pancreas / blood supply* Pancreatitis / drug therapy*, physiopathology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Trimetazidine: is it a promising drug for use in steatotic grafts?
Next Document: Expression, purification and characterization of enterovirus-71 virus-like particles.