Document Detail

Epidural adhesions after chymopapain chemonucleolysis.
MedLine Citation:
PMID:  2709355     Owner:  NLM     Status:  MEDLINE    
Epidural adhesions were discovered in seven of nine patients undergoing surgery for failed chymopapain chemonucleolysis. Clinically the adhesions were very vascular, prolific and adherent to the nerve root, dura and the porieties. The histological composition was similar to the normal tissues of the epidural space from the post-mortem controls and also to adhesions discovered at surgery in a non-injected patient, except that there was an increase in fibrous tissue, which was poorly cellular. There was no evidence of an inflammatory infiltrate. Such adhesions may partly explain the failure of chemonucleolysis and prejudice the success of surgery by potentiating further adhesion formation.
R T Austin; J A Zuk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Royal College of Surgeons of Edinburgh     Volume:  34     ISSN:  0035-8835     ISO Abbreviation:  J R Coll Surg Edinb     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503110     Medline TA:  J R Coll Surg Edinb     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  30-2     Citation Subset:  IM    
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MeSH Terms
Chymopapain / therapeutic use*
Epidural Space / pathology*
Intervertebral Disk Chemolysis / adverse effects*
Intervertebral Disk Displacement / drug therapy*
Middle Aged
Sciatica / drug therapy
Spinal Canal / pathology*
Tissue Adhesions
Reg. No./Substance:
Comment In:
J R Coll Surg Edinb. 1989 Aug;34(4):227   [PMID:  2810189 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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