| Epididymovasostomy as the first-line treatment of obstructive azoospermia in young couples with normal spermatogenesis. | |
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MedLine Citation:
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PMID: 20219429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the management of obstructive azoospermia (OA), microsurgery is often replaced by testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). Testicular biopsy and microsurgical side-to-side epididymovasostomy were performed in 34 azoospermic men with OA mostly due to inflammation. Ductal system patency was recovered in 21 (63.6%) men and natural pregnancy achieved in 13 (38.2%) of couples. Using multiple logistic regression analysis, it was found that ductal system patency and pregnancy were influenced by male and female age and testicular histology. The chance of obtaining patency was three times higher when male age was <38 years and two times higher when normal spermatogenesis alone was found to be present compared with mixed lesions. The chance of achieving a pregnancy was three times higher when the female partner's age was <29 years or normal spermatogenesis alone was present. The pregnancy rates obtained after surgery were not statistically different from those obtained by TESE-ICSI, but when also considering multiple pregnancies, miscarriages and side effects, the results obtained with surgery are better than those obtained with TESE-ICSI. |
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Authors:
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Tomaz Smrkolj; Irma Virant-Klun; Jasna Sinkovec; Ciril Oblak; Branko Zorn |
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Publication Detail:
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Type: Journal Article Date: 2010-02-01 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 20 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: Netherlands |
Other Details:
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Languages: eng Pagination: 594-601 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Andrology Centre, Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slajmerjeva 3, Ljubljana, Slovenia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Azoospermia / physiopathology, surgery* Epididymis / surgery* Female Humans Male Middle Aged Pregnancy Spermatogenesis* Vas Deferens / surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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