Document Detail


Epidermolysis bullosa acquisita associated with psoriasis vulgaris.
MedLine Citation:
PMID:  17459071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of epidermolysis bullosa acquisita (EBA) associated with psoriasis vulgaris. A 71-year-old woman with psoriasis vulgaris developed subepidermal blisters on the extremities. Direct immunofluorescence demonstrated linear deposit of IgG at the basement membrane zone, which bound to the dermal side of normal human skin split with 1 mol/L NaCl. Immunoblot analysis using recombinant full-length type VII collagen detected a 290-kDa band, confirming the diagnosis of EBA. A literature search for previous reports found a few cases of EBA associated with psoriasis, and all cases, including our own, presented with widespread inflammatory vesicles and bullae, and responded to conventional therapy with corticosteroids and immunosuppressive agents. This study suggests that western blotting using recombinant full-length type VII collagen could be useful for diagnosis of EBA, and that EBA associated with psoriasis may have a tendency to be the inflammatory type.
Authors:
D Hoshina; D Sawamura; T Nomura; S Tanimura; M Abe; T Onozuka; K Kodama; M Akiyama; H Shimizu
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-04-24
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  32     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  516-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. hoshina@med.hokudai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Infective Agents / therapeutic use
Dapsone / therapeutic use
Drug Therapy, Combination
Epidermolysis Bullosa Acquisita / drug therapy,  etiology*,  pathology
Female
Fluorescent Antibody Technique, Direct
Glucocorticoids / therapeutic use
Humans
Prednisolone / therapeutic use
Psoriasis / complications*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Glucocorticoids; 50-24-8/Prednisolone; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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