| Epidermolysis bullosa acquisita associated with psoriasis vulgaris. | |
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MedLine Citation:
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PMID: 17459071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of epidermolysis bullosa acquisita (EBA) associated with psoriasis vulgaris. A 71-year-old woman with psoriasis vulgaris developed subepidermal blisters on the extremities. Direct immunofluorescence demonstrated linear deposit of IgG at the basement membrane zone, which bound to the dermal side of normal human skin split with 1 mol/L NaCl. Immunoblot analysis using recombinant full-length type VII collagen detected a 290-kDa band, confirming the diagnosis of EBA. A literature search for previous reports found a few cases of EBA associated with psoriasis, and all cases, including our own, presented with widespread inflammatory vesicles and bullae, and responded to conventional therapy with corticosteroids and immunosuppressive agents. This study suggests that western blotting using recombinant full-length type VII collagen could be useful for diagnosis of EBA, and that EBA associated with psoriasis may have a tendency to be the inflammatory type. |
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Authors:
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D Hoshina; D Sawamura; T Nomura; S Tanimura; M Abe; T Onozuka; K Kodama; M Akiyama; H Shimizu |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2007-04-24 |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 32 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-13 Completed Date: 2008-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 516-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. hoshina@med.hokudai.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Infective Agents / therapeutic use Dapsone / therapeutic use Drug Therapy, Combination Epidermolysis Bullosa Acquisita / drug therapy, etiology*, pathology Female Fluorescent Antibody Technique, Direct Glucocorticoids / therapeutic use Humans Prednisolone / therapeutic use Psoriasis / complications* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Glucocorticoids; 50-24-8/Prednisolone; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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