| Epidermal keratinocytes of bullous pemphigoid express intercellular adhesion molecule-1 (ICAM-1). | |
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MedLine Citation:
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PMID: 1377725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intercellular adhesion molecule-1 (ICAM-1) is the ligand for lymphocyte function associated antigen-1 (LFA-1), mediating the adhesion of lymphocytes to vascular endothelium. Keratinocytes are known to express ICAM-1 in some inflammatory dermatoses. Using an indirect immunofluorescence method, we examined the patterns of ICAM-1 and LFA-1 staining in bullous pemphigoid (BP) lesions and compared them to pemphigus vulgaris (PV) cases. ICAM-1 was expressed on the cell surface and in the cytoplasm of epidermal keratinocytes at the sites of erythematous and bullous lesions of BP. LFA-1 molecules were expressed on T cells at the basement membrane zone. In addition, HLA-DR-positive keratinocytes were observed in the basal layer. ICAM-1 was not, however, expressed on epidermal keratinocytes in uninvolved skin from BP patients, PV or normal control skin. It is known that ICAM-1 is expressed on keratinocytes at the site of lymphoid infiltration in cutaneous dermatoses and that LFA-1-positive T cells can bind to interferon gamma-induced ICAM-1-positive keratinocytes. Our results suggest that cellular immunity involving ICAM-1 and LFA-1 may play a part in the pathogenesis of bullous pemphigoid. |
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Authors:
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T Karashima; H Hachisuka; K Okubo; Y Sasai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 19 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-08-03 Completed Date: 1992-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 82-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Kurume University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Adhesion
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immunology,
physiology Cell Adhesion Molecules / analysis*, immunology Fluorescent Antibody Technique Humans Intercellular Adhesion Molecule-1 Keratinocytes / immunology*, pathology, ultrastructure Lymphocyte Function-Associated Antigen-1 / analysis*, physiology Lymphocytes / immunology* Pemphigoid, Bullous / immunology, pathology* Skin / immunology, pathology*, ultrastructure Staining and Labeling / methods |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Lymphocyte Function-Associated Antigen-1; 126547-89-5/Intercellular Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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