Document Detail


Epidermal and hepatic glucocorticoid receptors in cats and dogs.
MedLine Citation:
PMID:  1620963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low capacity, high affinity [3H] dexamethasone binding receptors were identified in cytosolic preparations of liver (mean number 45 +/- 10.1 fmol mg-1 protein, apparent dissociation constant 0.4 +/- 0.1 nM) and skin (mean number 46.4 +/- 23.8 fmol mg-1 protein, apparent dissociation constant 1 +/- 0.2 nM) of clinically normal dogs. For clinically normal cats, approximately half these numbers of receptors with a lower affinity, were detected in liver (mean number 23.1 +/- 10.4 fmol mg-1 protein, apparent dissociation constant 3.2 +/- 0.9 nM) and skin (mean number 23.90 +/- 10.9 fmol mg-1 protein, apparent dissociation constant 2.2 +/- 1.5 nM). This difference between dogs and cats in [3H] dexamethasone binding receptors may contribute to the relative glucocorticoid resistance observed in cats.
Authors:
A H van den Broek; W L Stafford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  52     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  312-5     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Studies, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Summerhall.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats / metabolism*
Dexamethasone / metabolism
Dogs / metabolism*
Epidermis / chemistry,  metabolism*
Liver / chemistry,  metabolism*
Rats
Receptors, Glucocorticoid / analysis*
Chemical
Reg. No./Substance:
0/Receptors, Glucocorticoid; 0/dexamethasone receptor; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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