| Epidermal growth factor stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides but does not affect phosphoinositide breakdown by phospholipase C in renal cortical slices. | |
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MedLine Citation:
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PMID: 2830907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of epidermal growth factor (EGF) on the metabolism of phosphatidic acid and phosphoinositides were examined using renal cortical slices labelled with either sodium [32P]orthophosphate or myo-[3H]inositol. EGF was found to increase the incorporation of phosphate into phosphatidic acid and phosphoinositides. This effect is not dependent on external calcium and is inhibited by 12-O-tetradecanoylphorbol 13-acetate (TPA). When phospholipids were prelabelled, EGF did not decrease the level of 32P in phosphatidic acid and phosphoinositides, and EGF did not affect the formation of inositol phosphates or the concentration of cAMP and cGMP in renal tissue. The results show that EGF stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides, but does not affect breakdown of phosphoinositides by phospholipase C in renal cortical slices. |
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Authors:
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Z Gatalica; H Banfić |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 968 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-04-12 Completed Date: 1988-04-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 379-84 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, University of Zagreb, Yugoslavia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / pharmacology Culture Techniques Cyclic AMP / metabolism Cyclic GMP / metabolism Epidermal Growth Factor / pharmacology* Female Inositol Phosphates / biosynthesis Kidney Cortex / drug effects*, enzymology, metabolism Phosphates / metabolism* Phosphatidic Acids / metabolism* Phosphatidylinositols / metabolism* Rats Rats, Inbred Strains Tetradecanoylphorbol Acetate / pharmacology Type C Phospholipases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Inositol Phosphates; 0/Phosphates; 0/Phosphatidic Acids; 0/Phosphatidylinositols; 16561-29-8/Tetradecanoylphorbol Acetate; 60-92-4/Cyclic AMP; 62229-50-9/Epidermal Growth Factor; 7440-70-2/Calcium; 7665-99-8/Cyclic GMP; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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