Document Detail

Epidermal growth factor receptor mutations in multicentric lung adenocarcinomas and atypical adenomatous hyperplasias.
MedLine Citation:
PMID:  18448997     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The mechanisms of generation and progression of multicentric lung adenocarcinoma (AD), bronchioloalveolar carcinoma (BAC), and atypical adenomatous hyperplasia (AAH) in the peripheral lung is not well known. In this study, we analyzed epidermal growth factor receptor (EGFR) mutations in the cases of multicentric AD, BAC, and AAH to reveal the role of EGFR mutation in their generations and progressions. METHOD: Ninety-seven AAH, BAC, or AD lesions less than 3 cm in size in 26 patients were surgically resected. Of these, EGFR mutations of the nodules with the highest and the second highest grade of histologic malignancy were examined in each patient by using the peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA PCR) clamp method. RESULTS: EGFR mutations could be examined in 48 nodules in the 26 patients. The EGFR mutations were found more frequently in lesions with higher histologic malignancy, ie, 9 of 10 ADs (90%), 16 of 28 BACs (57%), and one of 10 AAHs (10%). In 22 patients who could be examined of EGFR mutations for the two lesions in each patient, only two patients (9%) had the same mutation patterns between the two lesions, whereas 15 patients (68%) had the different statuses and the remaining five (23%) had no mutations. CONCLUSION: Our data demonstrated that EGFR mutations seem to contribute to the acquisition of malignant potential in the AAH-AD sequence and occur independently in each lesion and in the cases of multicentric AD, BAC, and AAH.
Koei Ikeda; Hiroaki Nomori; Yasuomi Ohba; Hidekatsu Shibata; Takeshi Mori; Yumi Honda; Ken-Ichi Iyama; Toshiaki Kobayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer     Volume:  3     ISSN:  1556-1380     ISO Abbreviation:  J Thorac Oncol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-07-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101274235     Medline TA:  J Thorac Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-71     Citation Subset:  IM    
Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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MeSH Terms
Adenocarcinoma / genetics*,  surgery
Adenocarcinoma, Bronchiolo-Alveolar / genetics*,  surgery
Cell Transformation, Neoplastic / genetics
DNA Mutational Analysis
Hyperplasia / genetics,  surgery
Lung Neoplasms / genetics*,  surgery
Middle Aged
Polymerase Chain Reaction
Receptor, Epidermal Growth Factor / genetics*
Reg. No./Substance:
EC, Epidermal Growth Factor

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