Document Detail


Epidermal growth factor receptor function in early mammalian development.
MedLine Citation:
PMID:  7487966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We review here the data indicating a role for epidermal growth factor receptor (EGF receptor) signalling in early mouse development. Embryonic development of the metazoan embryo generally begins with the formation of a cystic structure and epithelial layers that subsequently form anlagen of the definitive body parts and organs. For the mammalian embryo, this cystic structure is a blastocyst whose wall consists of trophectoderm, the first epithelium to develop during mammalian embryogenesis. The onset of expression and function of EGF receptors is coincident with the onset of trophectoderm development. Modulating EGF receptor expression and function modulates trophectoderm differentiation, leading to the hypothesis that functional EGF receptors participate in the induction of trophectoderm development and perhaps of other embryonic epithelial derivatives such as nervous tissues.
Authors:
L M Wiley; E D Adamson; E C Tsark
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  17     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  839-46     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of California, Davis 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic and Fetal Development / physiology*
Mammals
Mice
Receptor, Epidermal Growth Factor / physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
CA 28427/CA/NCI NIH HHS; ES 05409/ES/NIEHS NIH HHS; HD 28025/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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