| Epidermal growth factor protects the heart against low-flow ischemia-induced injury. | |
| | |
MedLine Citation:
|
PMID: 20422337 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The role of ErbB4 and ErbB2 in the heart of adult mammals is well established. The heart also expresses ErbB1 (the epidermal growth factor (EGF) receptor), but this receptor has received less attention. We studied the effect of EGF on the response of isolated mouse heart to low-flow ischemia and reperfusion. Reducing perfusate flow to 10% for 30 min resulted in an increase in anaerobic metabolism and the leakage of lactate dehydrogenase during reperfusion. In addition, left ventricle +dP/dt and developed pressure were depressed (20-25%) during reperfusion. The addition of EGF 5 min before and throughout the ischemic period prevented the increase in anaerobic metabolism and the leakage of intracellular lactate dehydrogenase during reperfusion. EGF improved both +dP/dt and developed pressure during ischemia and prevented the decrease in dP/dt during reperfusion. To determine whether the effect of EGF on cell integrity depends on its effect on contractility, we studied nonbeating isolated myocytes. In these cells, anoxia and reoxygenation reduced cell viability by nearly 25%. EGF prevented such a decrease. Our results indicate that, like ErbB4 and ErbB2, ErbB1 also has an important role in the heart of adult animals. |
| | |
Authors:
|
J Lorita; M Soley; I Ramírez |
Related Documents
:
|
15161527 - Cardioprotective effects of mitochondrial katp channels activated at different time. 9563607 - Cardiac function and glycogen content after twenty-four-hour preservation with various ... 10789707 - Protective effect of jtv519, a new 1,4-benzothiazepine derivative, on prolonged myocard... 9475537 - Controlled reperfusion after lung ischemia: implications for improved function after lu... 1278067 - New instruments for measuring blood pressure. 17218877 - An ultracyclist with pulmonary edema during the bicycle race across america. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
|
Title: Journal of physiology and biochemistry Volume: 66 ISSN: 1138-7548 ISO Abbreviation: J. Physiol. Biochem. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-06-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812509 Medline TA: J Physiol Biochem Country: Spain |
Other Details:
|
Languages: eng Pagination: 55-62 Citation Subset: IM |
Affiliation:
|
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Massive Ethylene Glycol Ingestion Treated with Fomepizole Alone-A Viable Therapeutic Option.
Next Document: Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diab...