Document Detail

Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats.
MedLine Citation:
PMID:  18401831     Owner:  NLM     Status:  MEDLINE    
The physiological adaptations of the neonatal rat to hypoxia from birth include changes in gastrointestinal function and intermediary metabolism. We hypothesized that the hypoxic lactating dam would exhibit alterations in mammary gland function leading to changes in the concentration of milk peptides that are important in neonatal gastrointestinal development. The present study assessed the effects of chronic hypoxia on peptides produced by the mammary glands and present in milk. Chronic hypoxia decreased the concentration of epidermal growth factor (EGF) in expressed milk and pup stomach contents and decreased maternal mammary gland EGF mRNA. The concentration of parathyroid hormone-related protein (PTHrp) was unchanged in milk and decreased in pup stomach contents; however, mammary PTHLH mRNA was increased by hypoxia. There was a significant increase in adiponectin concentrations in milk from hypoxic dams. Chronic hypoxia decreased maternal body weight, and pair feeding normoxic dams an amount of food equivalent to hypoxic dam food intake decreased body weight to an equivalent degree. Decreased food intake did not affect the expression of EGF, PTHLH, or LEP mRNA in mammary tissue. The results indicated that chronic hypoxia modulated mammary function independently of hypoxia-induced decreases in maternal food intake. Decreased EGF and increased adiponectin concentrations in milk from hypoxic dams likely affect the development of neonatal intestinal function.
E D Bruder; J Van Hoof; J B Young; H Raff
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-06
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  40     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-10-06     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  446-53     Citation Subset:  IM    
Endocrine Research Laboratory, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, USA.
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MeSH Terms
Adiponectin / metabolism
Animals, Suckling
Anoxia / metabolism,  pathology*
Eating / genetics,  physiology
Epidermal Growth Factor / genetics*,  metabolism
Lactation* / genetics,  metabolism
Leptin / genetics,  metabolism
Mammary Glands, Animal / metabolism*
Milk / metabolism*
Parathyroid Hormone-Related Protein / genetics*,  metabolism
Postpartum Period / metabolism
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Grant Support
Reg. No./Substance:
0/Adiponectin; 0/Leptin; 0/Parathyroid Hormone-Related Protein; 0/RNA, Messenger; 62229-50-9/Epidermal Growth Factor

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