| Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats. | |
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MedLine Citation:
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PMID: 18401831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physiological adaptations of the neonatal rat to hypoxia from birth include changes in gastrointestinal function and intermediary metabolism. We hypothesized that the hypoxic lactating dam would exhibit alterations in mammary gland function leading to changes in the concentration of milk peptides that are important in neonatal gastrointestinal development. The present study assessed the effects of chronic hypoxia on peptides produced by the mammary glands and present in milk. Chronic hypoxia decreased the concentration of epidermal growth factor (EGF) in expressed milk and pup stomach contents and decreased maternal mammary gland EGF mRNA. The concentration of parathyroid hormone-related protein (PTHrp) was unchanged in milk and decreased in pup stomach contents; however, mammary PTHLH mRNA was increased by hypoxia. There was a significant increase in adiponectin concentrations in milk from hypoxic dams. Chronic hypoxia decreased maternal body weight, and pair feeding normoxic dams an amount of food equivalent to hypoxic dam food intake decreased body weight to an equivalent degree. Decreased food intake did not affect the expression of EGF, PTHLH, or LEP mRNA in mammary tissue. The results indicated that chronic hypoxia modulated mammary function independently of hypoxia-induced decreases in maternal food intake. Decreased EGF and increased adiponectin concentrations in milk from hypoxic dams likely affect the development of neonatal intestinal function. |
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Authors:
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E D Bruder; J Van Hoof; J B Young; H Raff |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-03-06 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 40 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-14 Completed Date: 2008-10-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 446-53 Citation Subset: IM |
Affiliation:
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Endocrine Research Laboratory, Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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metabolism Animals Animals, Suckling Anoxia / metabolism, pathology* Eating / genetics, physiology Epidermal Growth Factor / genetics*, metabolism Female Lactation* / genetics, metabolism Leptin / genetics, metabolism Male Mammary Glands, Animal / metabolism* Milk / metabolism* Parathyroid Hormone-Related Protein / genetics*, metabolism Postpartum Period / metabolism RNA, Messenger / metabolism Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DK54685/DK/NIDDK NIH HHS; R01 DK054685-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Leptin; 0/Parathyroid Hormone-Related Protein; 0/RNA, Messenger; 62229-50-9/Epidermal Growth Factor |
| Comments/Corrections | |
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