| Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells. | |
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MedLine Citation:
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PMID: 20959142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Members of the epidermal growth factor (EGF) family bind to ErbB (EGFR) family receptors which play an important role in the regulation of various fundamental cell processes including cell proliferation and differentiation. The normal rodent kidney has been shown to express at least three members of the ErbB receptor family and is a major site of EGF ligand synthesis. Polycystic kidney disease (PKD) is a group of diseases caused by mutations in single genes and is characterized by enlarged kidneys due to the formation of multiple cysts in both kidneys. Tubule cells proliferate, causing segmental dilation, in association with the abnormal deposition of several proteins. One of the first abnormalities described in cell biological studies of PKD pathogenesis was the abnormal mislocalization of the EGFR in cyst lining epithelial cells. The kidney collecting duct (CD) is predominantly an absorptive epithelium where electrogenic Na(+) entry is mediated by the epithelial Na(+) channel (ENaC). ENaC-mediated sodium absorption represents an important ion transport pathway in the CD that might be involved in the development of PKD. A role for EGF in the regulation of ENaC-mediated sodium absorption has been proposed. However, several investigations have reported contradictory results indicating opposite effects of EGF and its related factors on ENaC activity and sodium transport. Recent advances in understanding how proteins in the EGF family regulate the proliferation and sodium transport in normal and PKD epithelial cells are discussed here. This article is part of a Special Issue entitled: Polycystic Kidney Disease. |
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Authors:
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Nadezhda N Zheleznova; Patricia D Wilson; Alexander Staruschenko |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-10-16 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1812 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2011-10-19 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1301-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Epidermal Growth Factor / physiology* Epithelial Cells / pathology, physiology Epithelial Sodium Channels / physiology Humans Ion Transport Kidney / pathology, physiopathology Models, Biological Polycystic Kidney Diseases / etiology, pathology*, physiopathology* Polycystic Kidney, Autosomal Dominant / pathology, physiopathology Polycystic Kidney, Autosomal Recessive / pathology, physiopathology Receptor, Epidermal Growth Factor / physiology Sodium / metabolism* TRPP Cation Channels / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK62345/DK/NIDDK NIH HHS; P01 DK062345-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Epithelial Sodium Channels; 0/TRPP Cation Channels; 62229-50-9/Epidermal Growth Factor; 7440-23-5/Sodium; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
| Comments/Corrections | |
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