Document Detail


Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells.
MedLine Citation:
PMID:  20959142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Members of the epidermal growth factor (EGF) family bind to ErbB (EGFR) family receptors which play an important role in the regulation of various fundamental cell processes including cell proliferation and differentiation. The normal rodent kidney has been shown to express at least three members of the ErbB receptor family and is a major site of EGF ligand synthesis. Polycystic kidney disease (PKD) is a group of diseases caused by mutations in single genes and is characterized by enlarged kidneys due to the formation of multiple cysts in both kidneys. Tubule cells proliferate, causing segmental dilation, in association with the abnormal deposition of several proteins. One of the first abnormalities described in cell biological studies of PKD pathogenesis was the abnormal mislocalization of the EGFR in cyst lining epithelial cells. The kidney collecting duct (CD) is predominantly an absorptive epithelium where electrogenic Na(+) entry is mediated by the epithelial Na(+) channel (ENaC). ENaC-mediated sodium absorption represents an important ion transport pathway in the CD that might be involved in the development of PKD. A role for EGF in the regulation of ENaC-mediated sodium absorption has been proposed. However, several investigations have reported contradictory results indicating opposite effects of EGF and its related factors on ENaC activity and sodium transport. Recent advances in understanding how proteins in the EGF family regulate the proliferation and sodium transport in normal and PKD epithelial cells are discussed here. This article is part of a Special Issue entitled: Polycystic Kidney Disease.
Authors:
Nadezhda N Zheleznova; Patricia D Wilson; Alexander Staruschenko
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-16
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1812     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-10-19     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1301-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Epidermal Growth Factor / physiology*
Epithelial Cells / pathology,  physiology
Epithelial Sodium Channels / physiology
Humans
Ion Transport
Kidney / pathology,  physiopathology
Models, Biological
Polycystic Kidney Diseases / etiology,  pathology*,  physiopathology*
Polycystic Kidney, Autosomal Dominant / pathology,  physiopathology
Polycystic Kidney, Autosomal Recessive / pathology,  physiopathology
Receptor, Epidermal Growth Factor / physiology
Sodium / metabolism*
TRPP Cation Channels / physiology
Grant Support
ID/Acronym/Agency:
DK62345/DK/NIDDK NIH HHS; P01 DK062345-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Epithelial Sodium Channels; 0/TRPP Cation Channels; 62229-50-9/Epidermal Growth Factor; 7440-23-5/Sodium; EC 2.7.10.1/Receptor, Epidermal Growth Factor
Comments/Corrections

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