| Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytes. | |
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MedLine Citation:
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PMID: 19544429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New neurons and oligodendrocytes are continuously produced in the subventricular zone (SVZ) of adult mammalian brains. Under normal conditions, the SVZ primary precursors (type B1 cells) generate type C cells, most of which differentiate into neurons, with a small subpopulation giving rise to oligodendrocytes. Epidermal growth factor (EGF) signaling induces dramatic proliferation and migration of SVZ progenitors, a process that could have therapeutic applications. However, the fate of cells derived from adult neural stem cells after EGF stimulation remains unknown. Here, we specifically labeled SVZ B1 cells and followed their progeny after a 7-day intraventricular infusion of EGF. Cells derived from SVZ B1 cells invaded the parenchyma around the SVZ into the striatum, septum, corpus callosum, and fimbria-fornix. Most of these B1-derived cells gave rise to cells in the oligodendrocyte lineage, including local NG2+ progenitors, and pre-myelinating and myelinating oligodendrocytes. SVZ B1 cells also gave rise to a population of highly-branched S100beta+/glial fibrillary acidic protein (GFAP)+ cells in the striatum and septum, but no neuronal differentiation was observed. Interestingly, when demyelination was induced in the corpus callosum by a local injection of lysolecithin, an increased number of cells derived from SVZ B1 cells and stimulated to migrate and proliferate by EGF infusion differentiated into oligodendrocytes at the lesion site. This work indicates that EGF infusion can greatly expand the number of progenitors derived from the SVZ primary progenitors which migrate and differentiate into oligodendroglial cells. This expanded population could be used for the repair of white matter lesions. |
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Authors:
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Oscar Gonzalez-Perez; Ricardo Romero-Rodriguez; Mario Soriano-Navarro; Jose Manuel Garcia-Verdugo; Arturo Alvarez-Buylla |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Stem cells (Dayton, Ohio) Volume: 27 ISSN: 1549-4918 ISO Abbreviation: Stem Cells Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-01 Completed Date: 2010-01-13 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 9304532 Medline TA: Stem Cells Country: United States |
Other Details:
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Languages: eng Pagination: 2032-43 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, Brain Tumor Research Center, Institute for Regeneration Medicine, University of California, San Francisco, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Cell Differentiation / drug effects, physiology Cell Lineage Cell Movement / drug effects, physiology Cell Proliferation Cerebral Ventricles / cytology*, metabolism Demyelinating Diseases Epidermal Growth Factor / metabolism, pharmacology* Humans Mice Myelin Sheath / metabolism Neuroendocrine Cells / cytology Neurons / cytology*, drug effects, metabolism Oligodendroglia / cytology*, drug effects, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD 32116/HD/NICHD NIH HHS; R37 HD032116-15/HD/NICHD NIH HHS; R37 HD032116-16/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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62229-50-9/Epidermal Growth Factor |
| Comments/Corrections | |
Erratum In:
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Stem Cells. 2009 Dec;27(12):3122 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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