Document Detail

Epidermal growth factor in mice: changes during circadian and female reproductive cycles.
MedLine Citation:
PMID:  2284889     Owner:  NLM     Status:  MEDLINE    
To clarify the variation of mouse epidermal growth factor production during the 24-h and female reproductive cycles, we measured its concentrations in the plasma, submandibular salivary gland, urine, kidneys and liver of adult male and female mice during consecutive 12-h dark and 12-h light periods, different stages of pregnancy, and lactation. The concentration of epidermal growth factor in the submandibular gland showed no circadian changes. In plasma and in the liver it increased during the dark period, whereas in urine and in the kidneys it peaked in the daytime. In the submandibular gland the concentration decreased during early pregnancy, but it returned to the non-pregnant levels by mid-pregnancy. In plasma it decreased progressively during pregnancy and recovered during lactation. In urine and the kidneys the concentration of epidermal growth factor increased after early pregnancy; with a further great increase in the kidneys during lactation. In the liver the concentration was clearly below the non-pregnant levels during late pregnancy and lactation.
T Tuomela; L Viinikka; J Perheentupa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  123     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Children's Hospital, University of Helsinki, Finland.
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MeSH Terms
Circadian Rhythm*
Epidermal Growth Factor / blood,  metabolism*,  urine
Kidney / metabolism
Lactation / metabolism*
Liver / metabolism
Pregnancy, Animal / metabolism*
Submandibular Gland / metabolism
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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