Document Detail

Epidermal growth factor (EGF) expression in lateral line system and in taste buds of adult zebrafish (Brachidanio rerio).
MedLine Citation:
PMID:  16406323     Owner:  NLM     Status:  MEDLINE    
The mechano and chemosensory organs of adult teleosts undergoes a continuous cell renewal and turnover which is regulated in part by growth factors. Here, we investigated the occurrence and the cell localization of epidermal growth factor (EGF) in the lateral line system and taste bud of adult zebrafish, using Western blot and immunohistochemistry associated to a polyclonal antibody against mammalian EGF. Furthermore, the distribution of S100 protein was studied in parallel to label hair sensory cells in the lateral line system. Western blot revealed one unique protein band with an estimated molecular weight of about 13 kDa, equivalent to the EGF of mammals. Specific immunoreactivity for EGF was observed in the epithelial basal and/or supporting cells of the neuromasts of the lateral line system and taste buds. Conversely, the sensory cells in both sensory structures were devoid of immunostaining. Present results demonstrate the occurrence of EGF in mechano and sensory system of adult zebrafish, suggesting a role for this molecule in the cell renewal and turnover of these structures.
A Germanà; G Montalbano; F de Carlos; M B Levanti; F Abbate; J A Vega; E Ciriaco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-06
Journal Detail:
Title:  Neuroscience letters     Volume:  397     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  210-3     Citation Subset:  IM    
Dipartimento di Morfologia, Biochimica, Fisiologia e Produzione Animale, Sezione di Morfologia, Università di Messina, Polo Universitario Annunziata, 98168 Messina, Italy.
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MeSH Terms
Epidermal Growth Factor / biosynthesis*
Sense Organs / metabolism*
Taste Buds / metabolism
Zebrafish / metabolism*
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

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