| Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. | |
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MedLine Citation:
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PMID: 22293182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases. |
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Authors:
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Akiharu Kubo; Keisuke Nagao; Masayuki Amagai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-02-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-01 Completed Date: 2012-04-20 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 440-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Keio University School of Medicine, Shinanomachi 35, Shinjuku, Tokyo 160-8582, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dermatitis, Atopic / genetics, immunology*, pathology, physiopathology* Epidermis / anatomy & histology*, physiopathology* Humans Hypersensitivity, Immediate / immunology, pathology, physiopathology Intermediate Filament Proteins / genetics, immunology Mutation Skin / immunology*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Intermediate Filament Proteins; 0/filaggrin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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