| Epidermal Growth Factor and Gastrin on PDX1 Expression in Experimental Type 1 Diabetic Rats. | |
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MedLine Citation:
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PMID: 22270267 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: : The aim of this study was to investigate whether combined epidermal growth factor (EGF) and gastrin can correct the hyperglycemia induced by streptozotocin (STZ) in rats and to determine the involvement of the transcription factor pancreatic and duodenal homeobox 1 (PDX1) in this process. METHODS: : Rat diabetes was induced by intraperitoneal injection of STZ. The mRNA and protein levels of insulin and PDX1 were determined by real-time reverse transcriptase polymerase chain reaction and immunohistochemistry. Serum levels of C-peptide and insulin were analyzed using radioimmunoassay kits. RESULTS: : The combined administration of EGF and gastrin efficiently reversed the hyperglycemia induced by STZ. Elevated insulin concentration was detected in diabetic rats treated with EGF plus gastrin. The authors also found that both insulin and PDX1 expression were reduced in STZ-treated rats. Interestingly, the combination treatment also significantly enhanced the mRNA levels of insulin and PDX1, and that of their protein products. CONCLUSIONS: : Therapy with EGF plus gastrin corrected hyperglycemia and maintained insulin content in STZ-induced diabetic rats via up-regulation of PDX1 expression, suggesting that this combination treatment may provide a valuable approach for pancreatic islet neogenesis in vivo. |
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Authors:
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Haiying Yu; Zhonghua Sun; Junsheng Cui; Guohua Song; Fuqing Wang; Fenglan Gao; Xiaobin Liu; Xinrui Wang; Jinsong Ni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 343 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 141-5 Citation Subset: AIM; IM |
Affiliation:
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From the Key Laboratory of Pathology (HY, XL, JN), Ministry of Education, Norman Bethune Medical College, Jilin University, Changchun, China; Luohe Medical College (HY, GS, FW, FG), Luohe, China; Department of Endocrinology (ZS), First Clinical Hospital of Jilin University, Changchun, China; Department of Pathology (JC), Jilin Provincial Tumor Hospital, Changchun, China; and Key Laboratory of Zoonotic Diseases (XW), Ministry of Education, Jilin University, Changchun, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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