Document Detail

Epidemiology of viral hepatitis and hepatocellular carcinoma.
MedLine Citation:
PMID:  22537432     Owner:  NLM     Status:  MEDLINE    
Most cases of hepatocellular carcinoma (HCC) are associated with cirrhosis related to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Changes in the time trends of HCC and most variations in its age-, sex-, and race-specific rates among different regions are likely to be related to differences in hepatitis viruses that are most prevalent in a population, the timing of their spread, and the ages of the individuals the viruses infect. Environmental, host genetic, and viral factors can affect the risk of HCC in individuals with HBV or HCV infection. This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiologic studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the United States.
Hashem B El-Serag
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  142     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-06-18     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1264-1273.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
Section of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA.
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MeSH Terms
Aflatoxin B1 / poisoning
Biological Markers / blood
Carcinoma, Hepatocellular / epidemiology*,  virology*
Coinfection / epidemiology
Cost of Illness
DNA, Viral / isolation & purification
Epidemiologic Studies
Hepatitis B Surface Antigens / blood
Hepatitis B e Antigens / blood
Hepatitis B virus / genetics,  isolation & purification*,  physiology
Hepatitis B, Chronic / complications,  epidemiology*,  transmission
Hepatitis C, Chronic / complications,  epidemiology*
Liver Cirrhosis / complications,  epidemiology,  virology
Liver Neoplasms / epidemiology*,  virology*
Meta-Analysis as Topic
Risk Assessment
Risk Factors
United States / epidemiology
Virus Replication
World Health
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/DNA, Viral; 0/Hepatitis B Surface Antigens; 0/Hepatitis B e Antigens; 1162-65-8/Aflatoxin B1

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