| Epidemiology of restless legs syndrome: a synthesis of the literature. | |
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MedLine Citation:
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PMID: 21795081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Restless legs syndrome (RLS) has gained considerable attention in the recent years: nearly 50 community-based studies have been published in the last decade around the world. The development of strict diagnostic criteria in 1995 and their revision in 2003 helped to stimulate research interest on this syndrome. In community-based surveys, RLS has been studied as: 1) a symptom only, 2) a set of symptoms meeting minimal diagnostic criteria of the international restless legs syndrome study group (IRLSSG), 3) meeting minimal criteria accompanied with a specific frequency and/or severity, and 4) a differential diagnosis. In the first case, prevalence estimates in the general adult population ranged from 9.4% to 15%. In the second case, prevalence ranged from 3.9% to 14.3%. When frequency/severity is added, prevalence ranged from 2.2% to 7.9% and when differential diagnosis is applied prevalence estimates are between 1.9% and 4.6%. In all instances, RLS prevalence is higher in women than in men. It also increases with age in European and North American countries but not in Asian countries. Symptoms of anxiety and depression have been consistently associated with RLS. Overall, individuals with RLS have a poorer health than non-RLS but evidence for specific disease associations is mixed. Future epidemiological studies should focus on systematically adding frequency and severity in the definition of the syndrome in order to minimize the inclusion of cases mimicking RLS. |
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Authors:
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Maurice M Ohayon; Ruth O'Hara; Michael V Vitiello |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-07-26 |
Journal Detail:
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Title: Sleep medicine reviews Volume: 16 ISSN: 1532-2955 ISO Abbreviation: Sleep Med Rev Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-06-04 Completed Date: 2012-10-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9804678 Medline TA: Sleep Med Rev Country: England |
Other Details:
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Languages: eng Pagination: 283-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Stanford Sleep Epidemiology Research Center, Stanford University, School of Medicine, 3430 West Bayshore Road, Palo Alto, CA 94303, USA. mohayon@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Diagnosis, Differential Female Humans Male Middle Aged Pregnancy Pregnancy Complications / epidemiology Prevalence Restless Legs Syndrome / diagnosis, epidemiology* Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01NS044199/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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