Document Detail

Epidemiology of repeat ectopic pregnancy: a population-based prospective cohort study.
MedLine Citation:
PMID:  9464736     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study infectious pathology at index ectopic pregnancy and to determine what other factors predispose a woman to repeat ectopic pregnancy. METHODS: All women (n = 697) with their first (index) ectopic pregnancy histologically verified between January 1, 1978, and December 31,1993, at the only two hospitals in one Norwegian county were eligible. Included were permanent residents of the county who were 37 years of age or younger and who had not had tubal surgery before the index pregnancy. When the study closed on November 1, 1994, the participants had been observed prospectively for fertility events from approximately 1 to 17 years. Included in the final analyses were 353 women who had from one to five natural conceptions, for a total of 555 pregnancies. Chi-square test was used in univariate analysis, and the generalized estimating equations approach was used to analyze correlated responses and covariates that changed over time. RESULTS: Pregnancy order is the stronger correlate of subsequent ectopic pregnancy. The frequency of repeat ectopic pregnancy decreased by one-third for each pregnancy from the first to the third pregnancy. The odds of having another ectopic pregnancy were nearly three times higher for women with a diagnosis of infectious pathology than for women who had no infectious pathology. Other correlates of repeat ectopic pregnancy include age 24 years or younger at first ectopic pregnancy, history of repeat ectopic pregnancy, initiation of infertility work-up, and conception with an intrauterine device at index pregnancy. Method of surgery was not associated with repeat ectopic pregnancy. CONCLUSION: The most crucial reproductive event after first ectopic pregnancy is the first event to occur. Women who have experienced two ectopic pregnancies should be considered candidates for assisted reproduction.
F E Skjeldestad; A Hadgu; N Eriksson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  91     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Medical Faculty, Norwegian University of Science and Technology, Trondheim.
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MeSH Terms
Age Factors
Cohort Studies
Confidence Intervals
Follow-Up Studies
Medical Records
Norway / epidemiology
Odds Ratio
Pregnancy Outcome
Pregnancy, Ectopic / epidemiology*,  prevention & control
Prospective Studies
Recurrence / prevention & control
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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