Document Detail

Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review.
MedLine Citation:
PMID:  12498425     Owner:  NLM     Status:  MEDLINE    
Ovarian hyperstimulation syndrome (OHSS) is a rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy. Fortunately, the reported prevalence of the severe form of OHSS is small, ranging from 0.5 to 5%. Nevertheless, as this is an iatrogenic complication of a non-vital treatment with a potentially fatal outcome, the syndrome remains a serious problem for specialists dealing with infertility. The aim of this literature review was to determine whether it is possible to identify patients at risk, and which preventive method should be applied when an exaggerated ovarian response occurs. Data pertaining to the epidemiology and prevention of OHSS in women were searched using Medline, Current Contents and PubMed, and are summarized. Preventive strategies attempt either to limit the dose or concentration of hCG or to find a way to induce luteolysis without inducing a detrimental effect on endometrial and oocyte quality. The following particular preventive strategies were reviewed: cancelling the cycle; coasting; early unilateral ovarian follicular aspiration (EUFA); modifying the methods of ovulation triggering; administration of glucocorticoids, macromolecules and progesterone; cryopreservation of all embryos; and electrocautery or laser vaporization of one or both ovaries.
Annick Delvigne; Serge Rozenberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  8     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-05-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  559-77     Citation Subset:  IM    
IVF Centre, Department of Obstetrics-Gynaecology, University Hospital St Pierre (Free University of Brussels ULB), Belgium.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  adverse effects
Embryo, Mammalian
Infertility / therapy
Luteal Phase
Ovarian Hyperstimulation Syndrome / epidemiology*,  prevention & control*
Ovulation Induction / adverse effects
Polycystic Ovary Syndrome
Risk Factors
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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