Document Detail


Epidemiology of pleural mesothelioma in a population with non-occupational asbestos exposure.
MedLine Citation:
PMID:  18197921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: This study describes the epidemiology of malignant pleural mesothelioma (MPM) in a rural population with environmental asbestos exposure. METHODS: Patients with diagnosed MPM were recruited and their relevant demographic and exposure data were analysed. RESULTS: A total of 131 patients with MPM (59 men, 72 women) were studied. The patients' mean age was 57.8 years and the mean exposure duration was 28.9 years. The cumulative fibre count of the villagers ranged from 0.19 to 14.61 fibre/mL-years. Of the 131 patients, 85 had epithelial cell type, 20 had mixed, and eight had sarcomatous pleural mesothelioma. No significant relationship was found between asbestos fibre type and age, exposure period, or cellular type of MPM; similarly, no significant relationship could be found between the cellular type and age or exposure period. Patients with sarcomatous mesotheliomas were considerably older. Only five of 131 (3.8%) patients had a family history of mesothelioma. CONCLUSIONS: Environmental exposure to asbestos begins at birth and this may be important in the age of disease onset, if a threshold model for cancer initiation is operative. Both men and women had an excess risk of mesothelioma. Given that a family history of MPM was not common in this relatively homogenous patient group, a genetic predisposition to mesothelioma appears unlikely.
Authors:
Muzaffer Metintas; Selma Metintas; Guntulu Ak; Sinan Erginel; Fusun Alatas; Emel Kurt; Irfan Ucgun; Huseyin Yildirim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  13     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-05-07     Revised Date:  2009-02-03    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Affiliation:
Department of Chest Diseases, Osmangazi University Medical Faculty, Eskişehir, Turkey. metintas@superonline.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Asbestos / toxicity*
Carcinogens / toxicity*
Catchment Area (Health)
Environmental Exposure / adverse effects*
Female
Humans
Male
Mesothelioma / epidemiology*,  pathology
Middle Aged
Pleural Neoplasms / epidemiology*,  pathology
Prospective Studies
Rural Health*
Turkey
Chemical
Reg. No./Substance:
0/Carcinogens; 1332-21-4/Asbestos
Comments/Corrections
Comment In:
Respirology. 2008 Nov;13(6):931   [PMID:  18811894 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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