Document Detail


Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001.
MedLine Citation:
PMID:  16007587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The left ventricular outflow tract (LVOT) malformations aortic valve stenosis (AVS), coarctation of the aorta (CoA), and hypoplastic left heart syndrome (HLHS) contribute significantly to infant mortality due to birth defects. Previous epidemiology data showed rate differences between male and female and white and black ethnic groups. The Texas Birth Defects Registry, an active surveillance program, enables study in a large, diverse population including Hispanics.
METHODS: Records of children up to 1 year old with AVS, CoA, and HLHS born in Texas from 1999 to 2001, were collected from the registry. Those including additional heart defects or a chromosomal anomaly were excluded. Multivariate analysis included: infant sex; United States-Mexico border county residence; and maternal age, race/ethnicity, birthplace, and education.
RESULTS: There were 910 cases among 1.08 million live births, of which 499 met inclusion criteria. Multivariate modeling of all LVOT malformations combined demonstrated lower prevalence rate ratios (PRRs) for black males (0.26) and Hispanic males (0.70). Similar results were found for CoA but not AVS or HLHS. Higher PRRs were noted for increased maternal age for LVOT (1.3 for 24-34 years; 1.7 for >34 years), AVS, and HLHS, but not CoA, and higher PRRs across all diagnoses for males (LVOT PRR, 2.4) were noted. CoA PRRs were higher in border county vs. non-border county residents (PRR, 2.1). Maternal education and birthplace were not significant factors.
CONCLUSIONS: There are rate differences for males among all 3 ethnic groups. Sex and ethnic differences suggest genetic etiologies, where the ethnic differences could be used to find susceptibility loci with mapping by admixture linkage disequilibrium. Increased CoA rates along the U.S.-Mexico border suggest environmental causes that will require further monitoring.
Authors:
Kim L McBride; Lisa Marengo; Mark Canfield; Peter Langlois; David Fixler; John W Belmont
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  73     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2005-12-01     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  555-61     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc.
Affiliation:
Department of Molecular and Human Genetics, Columbus Children's Research Institute, Ohio State University, 43205, USA. mcbridek@ccri.net
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MeSH Terms
Descriptor/Qualifier:
Aortic Coarctation / epidemiology*,  ethnology,  mortality
Aortic Valve Stenosis / epidemiology*,  ethnology,  mortality
Continental Population Groups
Female
Humans
Hypoplastic Left Heart Syndrome / epidemiology*,  ethnology,  mortality
Infant
Infant, Newborn
Male
Maternal Age
Mexico
Multivariate Analysis
Pregnancy
Prevalence
Sex Factors
Texas
Ventricular Outflow Obstruction / congenital,  epidemiology
Grant Support
ID/Acronym/Agency:
K12 HD41648/HD/NICHD NIH HHS; K12 HD43372/HD/NICHD NIH HHS; K23 HL70823/HL/NHLBI NIH HHS; R01 HD039056-04/HD/NICHD NIH HHS; R01 HD39056/HD/NICHD NIH HHS; U50/CCU613232/CC/ODCDC CDC HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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