Document Detail


Epidemiology of neural tube defects in South America.
MedLine Citation:
PMID:  3907353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present data from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) on prevalence rates and etiologic factor associations in neural tube defects. Two series of data are analyzed: the A series, including 740,139 consecutive infants born in the 1967-1979 period suitable for secular trend analysis and case-control study of risk factors; and the B series, including 255,834 consecutive stillborn and liveborn infants of the 1980-1982 period suitable for prevalence rate analysis. Anencephaly was registered in 6.0/10,000 births, A spina bifida aperta in 6.2/10,000 births, and cephalocele in 2.4/10,000 births. A stable secular trend was observed for the frequency of all three neural tube defect types. Spina bifida was more frequent in Chile than in the rest of South America. No differences in prevalence rates were seen between tropical and non tropical areas. Parental consanguinity and environmental prenatal factors including maternal illnesses, drug intake, and radiation exposure were found in association with anencephaly and spina bifida.
Authors:
E E Castilla; I M Orioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  22     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1985-12-27     Completed Date:  1985-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anencephaly / epidemiology
Avitaminosis / complications
Climate
Geography
Humans
Neural Tube Defects / epidemiology*
Risk
South America
Spina Bifida Occulta / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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