| Epidemiology of neural tube defects in South America. | |
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MedLine Citation:
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PMID: 3907353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present data from the Latin American Collaborative Study of Congenital Malformations (ECLAMC) on prevalence rates and etiologic factor associations in neural tube defects. Two series of data are analyzed: the A series, including 740,139 consecutive infants born in the 1967-1979 period suitable for secular trend analysis and case-control study of risk factors; and the B series, including 255,834 consecutive stillborn and liveborn infants of the 1980-1982 period suitable for prevalence rate analysis. Anencephaly was registered in 6.0/10,000 births, A spina bifida aperta in 6.2/10,000 births, and cephalocele in 2.4/10,000 births. A stable secular trend was observed for the frequency of all three neural tube defect types. Spina bifida was more frequent in Chile than in the rest of South America. No differences in prevalence rates were seen between tropical and non tropical areas. Parental consanguinity and environmental prenatal factors including maternal illnesses, drug intake, and radiation exposure were found in association with anencephaly and spina bifida. |
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Authors:
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E E Castilla; I M Orioli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of medical genetics Volume: 22 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1985-12-27 Completed Date: 1985-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 695-702 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anencephaly
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epidemiology Avitaminosis / complications Climate Geography Humans Neural Tube Defects / epidemiology* Risk South America Spina Bifida Occulta / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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