Document Detail

Epidemiology of multiresistant Enterococcus avium isolates in a Greek tertiary care hospital.
MedLine Citation:
PMID:  12458137     Owner:  NLM     Status:  MEDLINE    
A retrospective survey of the isolation rate of Enterococcus avium during the period March 1994-February 2000 conducted in Laikon General Hospital using the WHONET software, revealed a peak in the isolation rates of this species during March 1995-February 1996. The ten strains isolated during this time were studied further. No glycopeptide resistance was detected but resistance to ampicillin, ciprofloxacin, erythromycin, gentamicin (high-level) and streptomycin (high-level) was present in nine, ten, nine, three and seven of the isolates, respectively. The genes aac(6')-Ie+aph(2")-Ia and ant(6)-I, encoding for high-level gentamicin and streptomycin resistance, respectively, were detected only in the isolates with the corresponding phenotypes. Beta-lactamase production and haemolysis were not detected. There was evidence of ward-, floor- and building-specific distribution among the different aminoglycoside resistance phenotypes. DNA fingerprinting by PFGE grouped six of the ten isolates in a single cluster with 83% similarity, even though they expressed various resistance phenotypes. These results suggest dissemination of resistance genes among both genetically related and unrelated strains.
Joseph Papaparaskevas; Panayotis T Tassios; Victoria Kalapothaki; Athina Avlami; Nicholas J Legakis; Alkiviadis C Vatopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  20     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-29     Completed Date:  2003-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  432-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V. and International Society of Chemotherapy
Clinical Microbiology Laboratory, Laikon General Hospital, Athens, Greece.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
DNA Fingerprinting
Drug Resistance, Multiple, Bacterial* / genetics
Enterococcus / classification,  drug effects*,  genetics
Gram-Positive Bacterial Infections / epidemiology*,  microbiology*
Greece / epidemiology
Retrospective Studies
Reg. No./Substance:
0/Anti-Bacterial Agents

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